Leprosy

projects 2008-2012

Treatment of early neuropathy in leprosy (TENLEP) trials

Principal Investigator Dr. Vanaja P. Shetty

Participating centers National JALMAInstitute for Leprosy and Other Mycobacterial Diseases, Agra, India.  Lalgadh hospital, Nepal. Nilphamari Leprosy Hospital, Bangladesh. Dr.Soetomo Hospital Surabaya , Indonesia

Collaborator with FMR Bombay Leprosy Project (Dr. VV Pai)

Project team Ms. Gospi Capadia, Dr. Kulbhushan Pawar, Dr. Ashish Khodke

Funders Netherlands Leprosy Relief; Turing Foundation; American Leprosy Missions; German Leprosy & TB Relief Association; Ordre de Malta

Duration January 2011 to December 2015

Budget Rs.96.67 Lakhs

Study design

International multi-centre randomized, double blind controlled trials in Leprosy patients from Brazil, Ethiopia, India, Indonesia and the Philippines

Objectives

  • To determine whether steroid treatment of early sub-clinical NFI detected with sensory or motor NC & WDT would be of prognostic benefit to patients in terms of sensory or motor function (MF, VMT, NC, WDT and activities of daily living).
  • To determine whether steroid treatment of 6 months duration is more effective than treatment of 4 months duration in restoring nerve function in patients with clinical sensory and/motor NFI of recent onset (<6 months).

Study outcomes

Primary and secondary outcome measures will include nerve function assessment, activities of daily living, reaction severity.

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