Principal Investigator Prof. Diana Lockwood
Collaborators London School of Hygiene & Tropical Medicine (LSHTM) [Diana Lockwood and Dr. Omer Haroun (LSHMT), Prof. Andrew Rice (CO PI) (Imperial College London)]
Project team Dr. Vanaja P Shetty (Co PI), Dr. Ashish Khodke
Funder The Hospital & Homes of St. Giles (HHSG),UK
Duration July 2012 to October 2013
Budget Rs.4.97 Lakhs
The overall aim of the study is to characterize the somatosensory phenotype of leprosy patients with chronic neuropathic pain.
Available data are far from satisfactory to understand the exact path-physiological related mechanisms of neuropathic pain in leprosy patients. Patients with painful neuropathy have impaired thermal and mechanical thresholds. Neuropathic pain has a higher impact on quality of life and psychological well being compared to pain-free neuropathy in leprosy patients. Therefore there is a pressing need to conduct studies to better understand the exact mechanisms of leprosy neuropathy and to design reasonable preventive and therapeutic modalities for chronic neuropathic pain in leprosy.
In this study we propose to assess somatosensory phenotype in leprosy patients with neuropathic pain using two tools: quantitative sensory testing (QST) and Intra-Epidermal Nerve Fibre density (IENF). There have been few studies examining both of these among leprosy patients.
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