Medicinal Plants

Projects

Development of an herbal package with antidiarrhoeal activity and its popularization in a rural community

Principal Investigator Dr. Tannaz  Birdi

Collaborator Dr. A. Natu, National Chemical Laboratory, Pune

Project Team Dr. Brijesh S, Ms. Poonam Daswani

Funder Indian Council of Medical Research

Duration January 2007-December 2009

Budget Rs.26.33 Lakhs

Key findings:

  • The results of the study suggest that the decoctions of all four plants used in the study viz. A. marmelos, C. rotundus, P. guajava and Z. officinale were effective in controlling the inflammatory response as was evident from the inhibition IFN-γ production.
  • The plants also enhanced the intracellular killing of stable toxin producing E. coli TXI by macrophages (Birdi et al., 2014).
  • Overall, P. guajava proved to be the most efficacious plant as it was the only plant which reduced the production of IL-8 in the post incubation protocol (Brijesh et al., 2011).
  • Studies with decoction of P. guajava in combination with the decoction of A. marmelos did not yield any increase benefit.
  • Studies with quercetin (one of the most biologically active constituents present in P. guajava leaves) and the decoction of P. guajava following removal of tannins showed that quercetin had limited activity whereas polyphenols (tannins) overall as a class of compounds were responsible for majority of the activities demonstrated by the decoction of P. guajava.
  • The information obtained from laboratory studies regarding the efficacy of P. guajava leaves as a treatment for diarrhoea was disseminated in the community with the assistance of local health worker women called Tais using public information networks. Information on the diarrhoeal episodes and the frequency of usage of P. guajava decoction as a choice of mode of treatment by the community along with reasons, if any, for not using were collected (Daswani et al., 2011).
  • It was observed that patients often took antibiotics for only one day and if symptoms decreased the antibiotic was discontinued. This could result in emergence of drug resistance.

Communicating to the community the plants efficacious for the treatment of diarrhoea as a follow up of the ethnobotanical survey undertaken through ‘Maitri’, a periodical newsletter pasted in public places

Communicating to the community the plants efficacious for the treatment of diarrhoea as a follow up of the ethnobotanical survey undertaken

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