Development of a Single Dose Formulation from Psidium guajava (guava) leaves
Principal Investigator Dr. Tannaz Birdi
Collaborator Dr. R. Vishwakarma, IIIM, Jammu and Dr. Geetha Krishnan, Medanta Hospital, Gurgaon.
Project Team Dr. Pooja Gupta, Ms. Poonam Daswani
Funder Preliminary work undertaken through Corpus Grant to FMR from Jamsetji Tata Trust (2011-2014)
An industrial partner needs to be identified for undertaking the manufacture and marketing of PGL formulation and taking the work forward.
Duration 3 years
Preliminary work done
The data on seasonal and regional variation has been generated. The extract at 1% shows minimal variation.
This shows that irrespective of the season or the location from which guava may be collected, its leaves will exhibit anti-diarrhoeal activity. Hence the SDF can be developed from guava leaves collected anytime from any location.
The toxicity studies have been carried out at IIIM, Jammu. The extract was found to be non-toxic at 2000mg/kg body weight p.oand has been classified as category 5 as per Globally Harmonized System of Classification of Chemicals (GHS) of Organization for Economic Co-operation and Development (OECD).
In the absence of a formulation, the Integrated Medicine Department of Medanta hospital under Dr. Geetha Krishnan’s supervision has treated 10 cases of diarrhoea with a freshly prepared aqueous PGL extract. The results have been encouraging
Plan of study
Stability of extract
Designing of a formulation
Shelf life and toxicity of formulation
Efficacy of formulation in an animal model
Proof of concept- Open efficacy trial
The Foundation was invited by the Department of Ayush, Government of India, Ministry of Health & Family Welfare to prepare a Detailed Project Report (DPR) on establishment of a North Eastern Institute of Folk Medicine, Pasighat under Centre of Excellence for Local Health Traditions for the North East – February 2007.