-20o & –80o Deep freezers for biological sample storage2
HPTLC for phytochemistry of medicinal plants
Inverted phase contrast microscope
BOD incubator in P2 facility for TB research2
Sterile room to undertake detailed water testing2
The Foundation for Medical Research always strives to stay abreast with relevant technology to support its research objectives.
Read about our facilities, and donate to help us expand them.
The FMR library collection comprises of scientific journals, reprints, books, proceedings of various conferences, annual reports and latest product catalogues along with price list of lab ware, lab equipment and chemicals.
The total number of subscribed scientific journals is 13. The list of these journals is as follows:
Down To Earth
National Medical Journal
Journal of Infectious Diseases
Medicinal and Aromatic Plant Abstracts (M A P A)
Trends in Microbiology
Trends in Immunology
"American Society of Microbiology - A S M (online subscription to 11 journals – as listed below)
Additionally, there are over 7400 reprints and 1400 books. Alterations in journal holdings and reprint collection are based annually on the scope of scientific work undertaken at the Institute and the topics of current interest, encompassing a wide range of subjects besides immediate concerns. All FMR Publications are also available for reference.
The library also maintains an exhaustive historical collection of leprosy journals.
Subject gateways, Email-alerts, Table of Contents are provided to staff and student as per their interest area. Inter-library loan service is also provided by library.
The services of library are open to all external users. Photocopy service is provided to the external users on payment.
The library holdings are computerized. The library is using RefWorks package database for information retrieval.
For further details contact: firstname.lastname@example.org
The Animal House facility includes random out bred Swiss White mice and inbred C57BL/6 mice.
The tissue culture complex is a self contained unit. It has four independent rooms (with seven laminar air flows), a preparation room, a sterilization room and a washroom.
Work involving agents with a potential for respiratory transmission and which may cause disease as a result of exposure by the inhalation route necessitates certain minimum biosafety requirements. Procedures such as processing of sputum samples from TB patients/ suspects, culturing of these samples, drug susceptibility testing and extraction of DNA from viable bacteria isolated from the samples are therefore carried out in a room equipped with a negative pressure (P2) facility. This ensures that ventilation to the laboratory is balanced to provide unidirectional airflow into the room. All the laboratory procedures which involve manipulation of infectious material are conducted within biological safety cabinets with 100% exhaust by personnel wearing appropriate protective clothing. A secondary barrier for this level of biosafety includes controlled access to the laboratory and ventilation requirements that minimize the release of infectious aerosols from the laboratory. Since the cabinet air has passed through the exhaust HEPA filter, it is contaminant - free and is ducted outdoors. Such safety measures are vital since the bacterial isolates could be multi - drug resistant.
Clinical services are strengthened by availability of histopathological facilities. Biopsies from human (skin and nerve) and mouse tissues are routinely done processed. FMR also receives referral nerve biopsies from within and around Mumbai for differential diagnosis. Triff is the preferred stain for tissue biopsies.
Immunocytochemistry using peroxidase conjugated antibodies like (SMI 31, BCG,CD4+, CD8+, T cells) are undertaken depending on the specific needs of research projects of the Foundation. Part of biopsies are kept at -70°C –thus a vast tissue bank for future use is available.
The Foundation's Clinic, staffed by two physicians, one electro diagnostician/physiotherapist and a surgical operation theatre continues to provide support services for the research undertaken. A plastic surgeon visits the clinic when required and conducts surgical procedures including nerve biopsies.
Few patients present directly to the clinic; while most patients are referred by other leprosy organizations and private practitioners as per the requirements of specific projects under way at the Foundation.
Patients registered at the clinic are provided with complete out-patient care, multidrug therapy/reaction management for leprosy and surgical care, whenever required. The routine investigations performed on all patients include slit-skin smears, histopathology and PCR based test. FMR is also fully equipped to carry out nerve Function Impairment Test (NFI) including electrophysiology and thermal test.
The tuberculosis department at FMR is actively engaged in genotyping of mycobacterial strains by spoligotyping and MIRU-VNTR analysis, genotypic detection of multidrug resistant (MDR) Mycobacterium tuberculosis strains, polymerase chain reaction (PCR) for gene amplification using linear/gradient thermal cyclers, DNA/RNA/protein analysis by agarose and/or polyacrylamide gel electrophoresis, gel documentation system, and real-time PCR setup for qualitative and quantitative transcriptional profiling.
In leprosy department too, molecular techniques are used for genotypic detection of multidrug resistant (MDR) Mycobacterium leprae strains. DNA is extracted from patient biopsies and amplified using PCR to check for DR DR (Drug Resistance Determining Regions) viz., folP1 (for dapsone), rpoB (for rifampicin) and gyrA (for ofloxacin).
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